姓名 | 吴彬 | 性别 | 男 |
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职称 | 助理研究员 | |||
研究方向 | 疼痛 | |||
电子邮箱 | ||||
个人简介 | 博士，同济大学附属养志康复医院心肺及重症康复中心助理研究员。博士毕业于生物信息工程专业，曾于美国印第安纳大学医学院从事博士后研究工作，主要研究方向为疼痛和瘙痒的分子与神经机制。 迄今共发表SCI收录论文二十余篇。主持国家自然科学基金青年项目1项、江苏省高校自然科学基金项目1项；作为核心成员参与国家自然科学基金重点项目1项、面上项目4项。研究聚焦于痛觉与瘙痒的神经及分子调控机制，探索慢性疼痛与瘙痒的发病机制及潜在干预靶点。 | |||
主要成果 | 近五年论文发表： 1.Ge W, Feng Y, Zhang L, Wang QL, Zhang CW, Wang ZH, Zhou GK, Sun SY, Miao XH, Liu T, Wu B, Yan J. Endoplasmic Reticulum Stress in the Keratinocytes Contributes to Chronic Itch by Activation of Lipocalin 2/MC4R/TRPV1 Pathway. Neurosci Bull. 2026 Feb 26. 2.Sun SY, Yin X, Ma JY, Wang XL, Xu XM, Wu JN, Zhang CW, Lu Y, Liu T, Zhang L, Kang PP, Wu B, Zhou GK. Histamine H4 receptor and TRPV1 mediate itch induced by cadaverine, a metabolite of the microbiome. Mol Pain. 2024 Jan-Dec;20:17448069241272149. 3.Wang B, Wang LN, Wu B, Guo R, Zhang L, Zhang JT, Wang ZH, Wu F, Feng Y, Liu H, Jin XH, Miao XH, Liu T. Astrocyte PERK and IRE1 Signaling Contributes to Morphine Tolerance and Hyperalgesia through Upregulation of Lipocalin-2 and NLRP3 Inflammasome in the Rodent Spinal Cord. Anesthesiology. 2024 Mar 1;140(3):558-577. 4.Tan ZY, Wu B, Su X, Zhou Y, Ji YH. Differential expression of slow and fast-repriming tetrodotoxin-sensitive sodium currents in dorsal root ganglion neurons. Front Mol Neurosci. 2024 Jan 11;16:1336664. 5.Zhou GK, Xu WJ, Lu Y, Zhou Y, Feng CZ, Zhang JT, Sun SY, Wang RM, Liu T, Wu B. Acid-sensing ion channel 3 is required for agmatine-induced histamine-independent itch in mice. Front Mol Neurosci. 2023 Mar 1;16:1086285. 6.Wu B, Su X, Zhang W, Zhang YH, Feng X, Ji YH, Tan ZY. Oxaliplatin Depolarizes the IB4- Dorsal Root Ganglion Neurons to Drive the Development of Neuropathic Pain Through TRPM8 in Mice. Front Mol Neurosci. 2021 Jun 4;14:690858. 7.Jiang ZJ, Mu D, Liu S, Jing PB, Wu B, Yang XM, Ge JY, Li QY, Chen HH, Zhang FM, Wang B, Zhang YY, Qian L, Zhu ZY, Ou YS, Sun SY, Luo L, Feng Y, Jiang C, Sun Z, Chen Y, Pan HL, Wang B, Gao FF, Wu J, Lu Z, Liu T, Sun YG, Liu XJ. Neuronal Endothelin a Receptor Mediates Experimental and Clinical Vascular Pain through an Endothelial-Neural Axis. Adv Sci (Weinh). 2025 Nov;12(42):e12375. | |||
